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This method demonstrates a catalyst-free approach to synthesize difluoroalkylated chroman-4-ones in various substrates, highlighting mechanisms.
We report a practical photochemical approach for alkene difluoroalkylacylation using easily available 2‐(allyloxy)arylaldehydes and bromodifluoroacetates (or bromodifluoroacetamides). This method features broad substrate scope and enables the efficient synthesis of various valuable RCF 2 ‐functionalized chroman‐4‐ones at room temperature. Key mechanistic insights show that the bifunctional bromodifluoroacetates (or bromodifluoroacetamides) act as both difluoroalkyl source and hydrogen atom acceptor. Consequently, the visible light‐driven difunctionalization of alkenes successfully proceeds without the need for external photocatalysts.
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Jia et al. (2025) studied this question.
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