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June 28, 2026Organic Letters

Visible-Light-Induced Difunctionalization of Alkenes with Masked Trifluoroacetyl Reagents

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Authors

PPPan PanSLShihao LiJCJ Chen

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Overview

Randomized trial demonstrates a new difunctionalization method for alkenes, suggesting a valuable synthesis route for trifluoroacetyl compounds.

Key Points

  • The study aims to develop a trifluoroacetylation difunctionalization reaction for electron-deficient alkenes using visible-light catalysis.
  • Utilized a combination of photoredox and palladium catalysis for trifluoroacetylation allylation.
  • Investigated mechanisms involving radical addition, reduction, and substitution processes.
  • Achieved trifluoroacetylation amination via an energy-transfer pathway.
  • Both protocols allow for mild reaction conditions and a broad substrate scope.
  • Provided a convenient strategy for synthesizing trifluoroacetyl building blocks.

Cite This Study

Pan et al. (2026) studied this question.

synapsesocial.com/papers/6a40ba2161bb0a67205c62dahttps://doi.org/10.1021/acs.orglett.6c02226
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