Characterisation of the Novel HLA‐DRB1*12:119 Allele by PacBio Sequencing

Key Points

• The research aims to characterize the novel HLA-DRB1*12:119 allele and identify its differences from a known allele.
• Conducted PacBio sequencing to characterize the allele.
• Identified nucleotide substitutions in exon 5.
• Analyzed intronic changes associated with the allele.
• HLA-DRB1*12:119 differs from DRB1*12:02:01:01 by a single nucleotide substitution.
• Intronic changes were documented, further defining the allele's genetic profile.