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March 30, 2026HLA

Characterisation of the Novel HLA‐DRB1*12:119 Allele by PacBio Sequencing

Shihang Zhou Wanzhen Yu Suning Bai Wenqian Song Xiaohua Liang

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Key Points

The research aims to characterize the novel HLA-DRB1*12:119 allele and identify its differences from a known allele.
Conducted PacBio sequencing to characterize the allele.
Identified nucleotide substitutions in exon 5.
Analyzed intronic changes associated with the allele.
HLA-DRB1*12:119 differs from DRB1*12:02:01:01 by a single nucleotide substitution.
Intronic changes were documented, further defining the allele's genetic profile.

Implication

Characterisation reveals nucleotide differences in HLA-DRB1 alleles, suggesting genetic variations in immune response.

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Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/69ccb6ce16edfba7beb88959 https://doi.org/10.1111/tan.70695

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