Altered neutrophil signalling linked to impaired chemotaxis and increased ROS and NET production in older people with frailty

Key Points

• To investigate the differences in neutrophil phenotype and function in older adults experiencing frailty compared to those aging in good health.
• Analyzed neutrophil signaling pathways in older adults with frailty and good health.
• Assessed chemotaxis ability, reactive oxygen species (ROS) production, and NET (neutrophil extracellular trap) formation.
• Compared findings to chronic inflammation observed in rheumatoid arthritis (RA).
• Older individuals with frailty demonstrate impaired chemotaxis compared to their healthier counterparts.
• Increased production of reactive oxygen species (ROS) was noted in neutrophils from frail individuals.
• Alterations in neutrophil phenotype showed similarities to chronic inflammation patterns seen in RA.