May 13, 2003

Third-Generation β-Blockers Stimulate Nitric Oxide Release From Endothelial Cells Through ATP Efflux

Structured PICO

Do third-generation β-blockers (nebivolol and carvedilol) stimulate nitric oxide release from endothelial cells?

Population

Renal glomerular endothelial cells (GECs) / renal glomerular microvasculature

Intervention

Nebivolol and carvedilol (third-generation β-blockers)

Outcome

Nitric oxide (NO) release and relaxation of renal glomerular microvasculaturesurrogate

Nebivolol and carvedilol induce relaxation of renal glomerular microvasculature via ATP efflux and NO release from endothelial cells.

Abstract

These results demonstrate for the first time that nebivolol and carvedilol induce relaxation of renal glomerular microvasculature through ATP efflux with consequent stimulation of P2Y-purinoceptor-mediated NO release from GECs.

Read Full Paperexternally

AI에게 질문

Bookmark

View Full Paper

Cite This Study

Kalinowski et al. (Tue,) studied this question.

synapsesocial.com/papers/69d570e975589c71d767e010 https://doi.org/https://doi.org/10.1161/01.cir.0000066912.58385.de

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

AI에게 질문

Bookmark

View Full Paper