Why the study?
Do third-generation β-blockers (nebivolol and carvedilol) stimulate nitric oxide release from endothelial cells?
Population
Renal glomerular endothelial cells (GECs) / renal glomerular microvasculature
Design
Preclinical
Authors
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Hypothesis-generating for renal microvascular effects of nebivolol and carvedilol; leaves open translation to human glomerular function.
Do third-generation β-blockers (nebivolol and carvedilol) stimulate nitric oxide release from endothelial cells?
Nebivolol and carvedilol induce relaxation of renal glomerular microvasculature via ATP efflux and NO release from endothelial cells.
Kalinowski et al. (2003) studied this question.
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