LMNA mutations account for 6.2% of familial DCM in Norway and are associated with high penetrance, frequent arrhythmias, and a high rate of heart transplantation, emphasizing the need for early family screening.
LMNA mutation prevalence was 6.2% of familial DCM in Norway. Cardiac penetrance was high in young asymptomatic LMNA genotype-positive family members with frequent AV block and VT, highlighting the importance of early family screening and cardiological follow-up. Nearly 20% of the LMNA patients required heart transplantation.
Hasselberg et al. (Sat,) studied this question.