Lamin A/C cardiomyopathy: young onset, high penetrance, and frequent need for heart transplantation

Figures

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  Figure 1. (A) Comparison of ages of documented penetrant cardiac phenotype between 48 lamin A/C genotype-positive probands and in 31 asymptomatic lamin A/C genotype-positive family members. Censored individuals still lacked the phenotype at last follow-up. (B) Kaplan–Meier plot showing time from genotype diagnosis to a documented penetrant cardiac phenotype in 31 asymptomatic lamin A/C genotype-positive family members. Censored individuals still lacked the phenotype at last follow-up.

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  Figure 2. (A) Kaplan–Meier plot showing better freedom from sustained ventricular arrhythmia (VA) in patients without atrioventricular (AV) block. (B) Kaplan–Meier plot showing better survival free from heart transplantation and death in patients with left ventricular ejection fraction (LVEF) ≥45% at presentation.