Why the study?
Does male sex worsen prognosis regarding major cardiac events and mortality in LMNA mutation carriers?
Does male sex worsen prognosis regarding major cardiac events and mortality in LMNA mutation carriers?
Male LMNA mutation carriers face a worse prognosis than females, driven by higher rates of malignant ventricular arrhythmias and end-stage heart failure.
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Male LMNA carriers may warrant closer arrhythmia/HF surveillance; leaves open whether sex-specific strategies improve outcomes.
This large cohort of LMNA mutation carriers demonstrates a high cardiac disease penetrance and a high mortality in mutation carriers. Male mutation carriers have a worse prognosis due to a higher prevalence of malignant ventricular arrhythmias and end-stage heart failure.
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Rijsingen et al. (2012) studied this question.
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