November 26, 2012Open Access
View Full PaperGender-Specific Differences in Major Cardiac Events and Mortality in Lamin A/C Mutation Carriers
Structured PICO
Does male sex worsen prognosis regarding major cardiac events and mortality in LMNA mutation carriers?
P
Population
LMNA mutation carriers
I
Intervention
Male sex
C
Comparator
Female sex
O
Outcome
Major cardiac events and mortalityhard clinical
Male LMNA mutation carriers face a worse prognosis than females, driven by higher rates of malignant ventricular arrhythmias and end-stage heart failure.
Abstract
This large cohort of LMNA mutation carriers demonstrates a high cardiac disease penetrance and a high mortality in mutation carriers. Male mutation carriers have a worse prognosis due to a higher prevalence of malignant ventricular arrhythmias and end-stage heart failure.