A Trial Comparing Nucleoside Monotherapy with Combination Therapy in HIV-Infected Adults with CD4 Cell Counts from 200 to 500 per Cubic Millimeter

Key Points

• The aim is to compare the efficacy of nucleoside monotherapy versus combination therapy in HIV-infected adults with specific CD4 counts.
• Compared treatments: zidovudine plus didanosine, zidovudine plus zalcitabine, and didanosine alone.
• Population: HIV-infected adults with CD4 counts from 200 to 500 cells/mm³.
• Analyzed survival rates and progression of HIV disease.
• Combination therapy is superior to zidovudine alone in slowing HIV progression.
• Increased survival rates observed in patients receiving combination therapy compared to monotherapy.