Randomized trial compares nucleoside monotherapy and combination therapy in HIV-infected adults, indicating better outcomes with combination treatment.
Treatment with zidovudine plus didanosine, zidovudine plus zalcitabine, or didanosine alone slows the progression of HIV disease and is superior to treatment with zidovudine alone. Antiretroviral therapy can improve survival in patients with 200 to 500 CD4 cells per cubic millimeter.
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Hammer et al. (1996) studied this question.
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