Does ultrasound-facilitated, catheter-directed thrombolysis improve outcomes compared to anticoagulation alone in patients with acute intermediate-high-risk pulmonary embolism?
The HI-PEITHO study is designed to evaluate ultrasound-facilitated, catheter-directed thrombolysis versus anticoagulation alone to establish first-line treatment for intermediate-high risk pulmonary embolism.
Regardless of the outcome, HI-PEITHO will establish the first-line treatment in intermediate-high risk PE patients with imminent hemodynamic collapse. The trial is expected to inform international guidelines and set the standard for evaluation of catheter-directed reperfusion options in the future.
Klok et al. (Mon,) studied this question.