May 16, 2022Open Access
Ultrasound-facilitated, catheter-directed thrombolysis vs anticoagulation alone for acute intermediate-high-risk pulmonary embolism: Rationale and design of the HI-PEITHO study
Key Points
- This research aims to determine the most effective treatment for patients with acute intermediate-high-risk pulmonary embolism.
- Randomized trial design comparing catheter-directed thrombolysis with anticoagulation alone.
Structured PICO
Does ultrasound-facilitated, catheter-directed thrombolysis improve outcomes compared to anticoagulation alone in patients with acute intermediate-high-risk pulmonary embolism?
P
Population
Patients with acute intermediate-high-risk pulmonary embolism with imminent hemodynamic collapse
I
Intervention
Ultrasound-facilitated, catheter-directed thrombolysis
C
Comparator
Anticoagulation alone
The HI-PEITHO study is designed to evaluate ultrasound-facilitated, catheter-directed thrombolysis versus anticoagulation alone to establish first-line treatment for intermediate-high risk pulmonary embolism.
Abstract
Regardless of the outcome, HI-PEITHO will establish the first-line treatment in intermediate-high risk PE patients with imminent hemodynamic collapse. The trial is expected to inform international guidelines and set the standard for evaluation of catheter-directed reperfusion options in the future.
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Authors
F
Frederikus A. Klok
Vascular Medicine
Gregory Piazza
Vascular Medicine
A
Andrew Sharp
Interventional Cardiology
Journals
American Heart Journal
Actions
Institutions
Harvard University
Brigham and Women's Hospital
Massachusetts General Hospital
References and Citations
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