November 29, 2010Open Access

The Dynamics of Naturally Acquired Immune Responses to Plasmodium falciparum Sexual Stage Antigens Pfs230 & Pfs48/45 in a Low Endemic Area in Tanzania

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Abstract

In a longitudinal study, anti-Pfs230 and Pfs48/45 antibodies developed rapidly after exposure to gametocytes and were strongly associated with transmission-reducing activity. Our data indicate that the extent of antigen exposure is important in eliciting functional transmission-reducing immune responses.

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Cite This Study

Bousema et al. (Mon,) studied this question.

synapsesocial.com/papers/69d99c0f0d540cafc58365f2 https://doi.org/https://doi.org/10.1371/journal.pone.0014114

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4Malaria transmission-blocking vaccines—how can their development be supported?2000 · 144 citations
5Substantial Contribution of Submicroscopical Plasmodium falciparum Gametocyte Carriage to the Infectious Reservoir in an Area of Seasonal Transmission2009 · 232 citations

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