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November 29, 2010SHILAP Revista de lepidopterologíaOpen Access

The Dynamics of Naturally Acquired Immune Responses to Plasmodium falciparum Sexual Stage Antigens Pfs230 & Pfs48/45 in a Low Endemic Area in Tanzania

Teun Bousema Will Roeffen Hinta Meijerink Harry Mwerinde Steve Mwakalinga Geert‐Jan van Gemert Marga van de Vegte‐Bolmer Frank Mosha Geoffrey Targett Eleanor M. Riley Robert W. Sauerwein Chris Drakeley

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Abstract

In a longitudinal study, anti-Pfs230 and Pfs48/45 antibodies developed rapidly after exposure to gametocytes and were strongly associated with transmission-reducing activity. Our data indicate that the extent of antigen exposure is important in eliciting functional transmission-reducing immune responses.

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Bousema et al. (2010) studied this question.

synapsesocial.com/papers/69d99c0f0d540cafc58365f2 https://doi.org/10.1371/journal.pone.0014114

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