Boosting the oxidase-mimicking activity of metal–organic framework nanozymes via heteroatom modulation in the organic linkers

Key Points

• The aim is to enhance the oxidase-like activity of metal-organic framework nanozymes through heteroatom modulation.
• Synthesized MIL-53(Fe) nanozymes using five-membered heterocyclic linkers.
• Replaced linear terephthalate linkers with heterocyclic analogues containing O or S.
• Measured the oxidase-like activity of different MIL-53(Fe) variants.
• MIL-53(Fe)-TDC variant shows a six-fold increase in oxidase-like activity.
• Heteroatoms lead to modulation of electron density at metal active sites.