Glycolytic metabolism of CD8 + T‐cells affects susceptibility to human leukocyte antigen‐mediated abacavir‐induced hypersensitivity

Key Points

• The research investigates how glycolytic metabolism in CD8+ T-cells affects susceptibility to HLA-mediated drug hypersensitivity, specifically from abacavir.
• Analyzed glycolytic metabolism in CD8+ T-cells
• Examined HLA interactions with abacavir
• Assessed hypersensitivity reactions
• Glycolytic metabolism plays a crucial role in HLA-mediated hypersensitivity reactions
• Certain metabolic pathways may increase susceptibility to drug hypersensitivity in humans