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Glycolytic metabolism influences HLA-mediated abacavir hypersensitivity in a human context, suggesting new pathways for understanding drug reactions.
Overall, these results suggest the indispensable role of glycolytic CD8⁺ T-cell metabolism in HLA-mediated abacavir-induced hypersensitivity reactions, which may further determine susceptibility to HLA-mediated drug hypersensitivity reactions in humans.
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Susukida et al. (2026) studied this question.
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