What question did this study set out to answer?

To determine how T-cell receptor (TCR) binding affinity to peptide-human leukocyte antigen complexes modulates metabolic pathway usage and functional responses in human CD4+ and CD8+ T-cells.

November 9, 2017Frontiers in ImmunologyOpen Access

Metabolic Adaptation of Human CD4+ and CD8+ T-Cells to T-Cell Receptor-Mediated Stimulation

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To determine how T-cell receptor (TCR) binding affinity to peptide-human leukocyte antigen complexes modulates metabolic pathway usage and functional responses in human CD4+ and CD8+ T-cells.
Analyzed baseline metabolic enzyme expression and pathway activities in human CD4+ and CD8+ T-cells.
Stimulated antigen-specific CD4+ and CD8+ T-cell clones with altered peptide ligands possessing varying TCR binding affinities.
CD4+ T-cells exhibited increased hexokinase II expression coupled with higher basal glycolysis compared to CD8+ T-cells.
CD8+ T-cell cytokine production showed preferential reliance on oxidative phosphorylation rather than glycolysis.
TCR-ligand binding affinity quantitatively tuned the underlying metabolic shifts across both CD4+ and CD8+ human T-cell subsets.

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Implication

In vitro study demonstrates that receptor binding affinity drives distinct metabolic reprogramming in human CD4+ and CD8+ T-cells, indicating pathways for targeted immunotherapies.

Cite This Study

Jones et al. (2017) studied this question.

synapsesocial.com/papers/6a757002e2936089dd034069 https://doi.org/10.3389/fimmu.2017.01516

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Implication

In vitro study demonstrates that receptor binding affinity drives distinct metabolic reprogramming in human CD4+ and CD8+ T-cells, indicating pathways for targeted immunotherapies.

Metabolic Adaptation of Human CD4+ and CD8+ T-Cells to T-Cell Receptor-Mediated Stimulation

Key Points

Discussion

Implication

Cite This Study

Metabolic Adaptation of Human CD4+ and CD8+ T-Cells to T-Cell Receptor-Mediated Stimulation

Key Points

Discussion

Implication

Cite This Study

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