Seizure-presenting IDH-wildtype glioblastoma and the upregulation of a synaptic signature

Key Points

• The aim is to investigate the characteristics and implications of seizure presentation in IDH-wildtype glioblastoma.
• Comparison of tumor volumes between seizure-presenting and non-seizure-presenting IDH-wildtype glioblastoma.
• Transcriptional analysis to identify synaptic and ionic pathway alterations.
• Assessment of the predictive value of SLC17A8 for seizure presentation.
• Tumors presenting with seizures were found to have smaller volumes compared to those with other presentations.
• Seizure presence correlated with the upregulation of synaptic and ionic pathways.
• SLC17A8 was identified as an independent predictor of seizure presentation.