Observational research finds smaller tumor volumes with seizure presentation in IDH-wildtype glioblastoma, suggesting key biochemical differences.
In IDH-wildtype GBM, tumors presenting with seizures had smaller volumes than those presenting with other signs. Transcriptionally, seizure presentation in IDH-wildtype GBM correlated with the upregulation of synaptic and ionic pathways, with SLC17A8 holding independent predictive value for seizure presentation.
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McDonald et al. (2026) studied this question.
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