July 1, 2017Open Access

Thromboembolic Risk, Bleeding Outcomes and Effect of Different Antithrombotic Strategies in Very Elderly Patients With Atrial Fibrillation: A Sub‐Analysis From the PREFER in AF ( PRE vention o F Thromboembolic Events– E uropean R egistry in A trial F ibrillation)

Structured PICO

Does oral anticoagulation improve net clinical benefit in very elderly patients with atrial fibrillation?

Population

Very elderly patients with atrial fibrillation

Intervention

Oral anticoagulation (OAC)

Outcome

Thromboembolic risk and bleeding outcomeshard clinical

In very elderly patients with atrial fibrillation, the absolute benefit of oral anticoagulation outweighs the bleeding risk, providing significant net clinical benefit.

Abstract

Because the risk of stroke increases with age more than the risk of bleeding, the absolute benefit of OAC is highest in very elderly patients, where it, by far, outweighs the risk of bleeding, with the greatest net clinical benefit in such patients.

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