Does oral anticoagulation improve net clinical benefit in very elderly patients with atrial fibrillation?
In very elderly patients with atrial fibrillation, the absolute benefit of oral anticoagulation outweighs the bleeding risk, providing significant net clinical benefit.
Because the risk of stroke increases with age more than the risk of bleeding, the absolute benefit of OAC is highest in very elderly patients, where it, by far, outweighs the risk of bleeding, with the greatest net clinical benefit in such patients.
Patti et al. (Sat,) studied this question.