Organocatalytic asymmetric 4 + 4-annulation reaction between ynones and benzylidene thiazolones: Synthesis of eight-membered ether containing 4,5-fused thiazoles

Key Points

• The aim is to develop an asymmetric (4 + 4)-annulation reaction using ynones and benzylidene thiazolones to create 4,5-fused thiazoles.
• Utilized aminocatalysis for enantioselective synthesis.
• Conducted reaction between ynones and benzylidene thiazolones.
• Characterized the resulting compounds to confirm structure and functionality.
• Successfully synthesized eight-membered ethers containing fused thiazoles.
• Demonstrated high enantioselectivity in the product formation.
• Provided a new method for synthesizing complex thiazole architectures.