Organocatalytic asymmetric [4 + 4]-annulation reaction between ynones and benzylidene thiazolones: Synthesis of eight-membered ether containing 4,5-fused thiazoles

Dipankar Barman; Subhas Chandra Pan

doi:10.1039/d6cc01689h

January 1, 2026Chemical Communications

Organocatalytic asymmetric [4 + 4]-annulation reaction between ynones and benzylidene thiazolones: Synthesis of eight-membered ether containing 4,5-fused thiazoles

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Key Points

The aim is to develop an asymmetric (4 + 4)-annulation reaction using ynones and benzylidene thiazolones to create 4,5-fused thiazoles.
Utilized aminocatalysis for enantioselective synthesis.
Conducted reaction between ynones and benzylidene thiazolones.
Characterized the resulting compounds to confirm structure and functionality.
Successfully synthesized eight-membered ethers containing fused thiazoles.
Demonstrated high enantioselectivity in the product formation.
Provided a new method for synthesizing complex thiazole architectures.

Implication

Describes an asymmetric process that creates eight-membered ethers in thiazole synthesis.

Abstract

An asymmetric (4 + 4)-annulation of benzylidene thiazolones and ynones by aminocatalysis is described. An enantioselective synthesis of eight-membered ether embedded 4,5-fused thiazoles is first reported in this work. The...

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Cite This Study

Barman et al. (2026) studied this question.

synapsesocial.com/papers/69e3216540886becb6540a06 https://doi.org/10.1039/d6cc01689h

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Organocatalytic asymmetric [4 + 4]-annulation reaction between ynones and benzylidene thiazolones: Synthesis of eight-membered ether containing 4,5-fused thiazoles

Key Points

Implication

Abstract

Discussion

Cite This Study

Organocatalytic asymmetric [4 + 4]-annulation reaction between ynones and benzylidene thiazolones: Synthesis of eight-membered ether containing 4,5-fused thiazoles

Key Points

Implication

Abstract

Discussion

Cite This Study

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