This research demonstrates asymmetric synthesis of thieno-fused lactams using green solvent, suggesting environmental benefits.
A mild and environmentally friendly construction of thieno-fused lactam scaffolds has been successfully developed through NHC-catalyzed [3 + 3] annulation of bromoenals and thiophen-3-amines. A diverse range of thieno[3,2-b]pyridinones were efficiently synthesized in moderate-to-excellent yields with good-to-excellent enantioselectivities. Notably, protecting-group-free thiophen-3-amines were compatible with this strategy in the presence of the green solvent 2-MeTHF.
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Shi et al. (2026) studied this question.
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