What question did this study set out to answer?

To assess the relationship between muscle function and vertebral fractures in individuals with Duchenne muscular dystrophy receiving glucocorticoid treatment.

April 19, 2026Osteoporosis International0 citationsOpen Access

Vertebral fractures and muscle function in glucocorticoid-treated individuals with Duchenne muscular dystrophy: a cohort study

ACAnna CapassoUniversità Cattolica del Sacro Cuore CAChiara ArpaiaUniversità Cattolica del Sacro Cuore CPChiara PanicucciIstituto Giannina Gaslini

Key Points

To assess the relationship between muscle function and vertebral fractures in individuals with Duchenne muscular dystrophy receiving glucocorticoid treatment.
Cohort study design
Assessment of ambulatory status and functional scores
Evaluation of risk factors including glucocorticoid initiation and BMD Z-scores
Ambulatory status and functional scores were not reliable predictors of vertebral fractures.
There was a confirmed association between early glucocorticoid therapy initiation and low BMD Z-scores.
The findings suggest a need for enhanced surveillance for vertebral fractures from glucocorticoid initiation.

Abstract

Our results suggest that ambulatory status and functional scores alone may not be reliable predictors for developing VFs and confirm the association with known risk factors, such as early initiation of glucocorticoid therapy and low BMD Z-scores, highlighting the need to guarantee a careful surveillance of possible VFs from the time of glucocorticoid initiation.

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