Vertebral fractures and muscle function in glucocorticoid-treated individuals with Duchenne muscular dystrophy: a cohort study

Anna Capasso; Chiara Arpaia; Chiara Panicucci; Consolato Gullì; Marianna Villa; Agnese Repetto; Giorgia Coratti; Simone Morando; Gianpaolo Cicala; Alessandro Oliva; Domenico Milardi; Clelia Cipolla; Gennaro Catapano; A Marzoli; Maria Beatrice Damasio; Claudia Brogna; Concetta Palermo; Natascia Di Iorgi; Claudio Bruno; Luana Ficociello; Simona Gaudino; Marika Pane; Leanne M. Ward; Eugenio Mercuri

doi:10.1007/s00198-026-07990-y

Key Points

To assess the relationship between muscle function and vertebral fractures in individuals with Duchenne muscular dystrophy receiving glucocorticoid treatment.
Cohort study design
Assessment of ambulatory status and functional scores
Evaluation of risk factors including glucocorticoid initiation and BMD Z-scores
Ambulatory status and functional scores were not reliable predictors of vertebral fractures.
There was a confirmed association between early glucocorticoid therapy initiation and low BMD Z-scores.
The findings suggest a need for enhanced surveillance for vertebral fractures from glucocorticoid initiation.

Implication

Cohort study finds muscle function scores are unreliable predictors of vertebral fractures in glucocorticoid-treated individuals, suggesting the need for careful monitoring.

Discussion

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Cite This Study

Capasso et al. (2026) studied this question.

synapsesocial.com/papers/69e47193010ef96374d8ddef https://doi.org/10.1007/s00198-026-07990-y

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Vertebral fractures and muscle function in glucocorticoid-treated individuals with Duchenne muscular dystrophy: a cohort study

Key Points

Implication

Discussion

Cite This Study

Vertebral fractures and muscle function in glucocorticoid-treated individuals with Duchenne muscular dystrophy: a cohort study

Key Points

Implication

Discussion

Cite This Study

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