What question did this study set out to answer?

This research aims to explore the relationship between RUNX2 variant types and craniofacial-dental traits in Cleidocranial Dysplasia (CCD).

April 19, 2026Open Access

Correlation of RUNX2 Variants With Craniofacial–Dental Phenotypes in Cleidocranial Dysplasia

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Key Points

This research aims to explore the relationship between RUNX2 variant types and craniofacial-dental traits in Cleidocranial Dysplasia (CCD).
Analyzed the influence of different RUNX2 variants on cranial base and maxillary morphology.
Assessed skeletal Class III severity related to RUNX2 variants.
Evaluated dental anomalies independent of variant types.
RUNX2 variant type significantly affects cranial base and maxillary morphology.
Skeletal Class III severity is associated with specific RUNX2 variants.
Dental anomalies do not correlate with the type of RUNX2 variant.

Abstract

RUNX2 variant type influences cranial base and maxillary morphology, contributing to skeletal Class III severity in CCD, whereas dental anomalies appear independent of variant type.

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Authors

Pintu-on Chantarawaratit

Chulalongkorn University

Sermporn Thaweesapphithak

Chulalongkorn University

Pisha Pittayapat

Chulalongkorn University

Journals

Clinical and Experimental Dental Research

Actions

Institutions

University of Zurich

Chulalongkorn University

Walailak University

References and Citations

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Cite this study

Chantarawaratit et al. (Wed,) studied this question.

synapsesocial.com/papers/69e4745f010ef96374d900fa — DOI: https://doi.org/10.1002/cre2.70351

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Development of the dentition in cleidocranial dysplasia· 1990 · 212 citations
Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development· 1997 · 2,814 citations
Pediatric Dentoalveolar Surgery· 2011 · 9 citations
A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research· 2016 · 27,260 citations
Process of maturation and growth prediction· 1963 · 56 citations

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Development of the dentition in cleidocranial dysplasia· 1990 · 212 citations
Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development· 1997 · 2,814 citations
Pediatric Dentoalveolar Surgery· 2011 · 9 citations
A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research· 2016 · 27,260 citations
Process of maturation and growth prediction· 1963 · 56 citations

Correlation of RUNX2 Variants With Craniofacial–Dental Phenotypes in Cleidocranial Dysplasia

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Also consider