What question did this study set out to answer?

This research aims to explore the relationship between RUNX2 variant types and craniofacial-dental traits in Cleidocranial Dysplasia (CCD).

April 19, 2026Clinical and Experimental Dental Research0 citationsOpen Access

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Correlation of RUNX2 Variants With Craniofacial–Dental Phenotypes in Cleidocranial Dysplasia

PCPintu-on ChantarawaratitChulalongkorn University STSermporn ThaweesapphithakChulalongkorn University PPPisha PittayapatChulalongkorn University

Key Points

This research aims to explore the relationship between RUNX2 variant types and craniofacial-dental traits in Cleidocranial Dysplasia (CCD).
Analyzed the influence of different RUNX2 variants on cranial base and maxillary morphology.
Assessed skeletal Class III severity related to RUNX2 variants.
Evaluated dental anomalies independent of variant types.
RUNX2 variant type significantly affects cranial base and maxillary morphology.
Skeletal Class III severity is associated with specific RUNX2 variants.
Dental anomalies do not correlate with the type of RUNX2 variant.

Abstract

RUNX2 variant type influences cranial base and maxillary morphology, contributing to skeletal Class III severity in CCD, whereas dental anomalies appear independent of variant type.

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Correlation of RUNX2 Variants With Craniofacial–Dental Phenotypes in Cleidocranial Dysplasia

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