Does increased workload alter cardiac energetics, oxygenation, and perfusion in patients with type 2 diabetes mellitus?
In patients with type 2 diabetes, coronary microvascular dysfunction exacerbates the derangement of cardiac energetics during increased workload.
The pre-existing energetic deficit in diabetic cardiomyopathy is exacerbated by exercise; stress PCr/ATP correlates with impaired perfusion and oxygenation. Our findings suggest that, in diabetes, coronary microvascular dysfunction exacerbates derangement of cardiac energetics under conditions of increased workload.
Levelt et al. (Sun,) studied this question.
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