Why the study?
Does increased workload alter cardiac energetics, oxygenation, and perfusion in patients with type 2 diabetes mellitus?
Does increased workload alter cardiac energetics, oxygenation, and perfusion in patients with type 2 diabetes mellitus?
In patients with type 2 diabetes, coronary microvascular dysfunction exacerbates the derangement of cardiac energetics during increased workload.
Coronary microvascular dysfunction may worsen exercise-induced energetic impairment in type 2 diabetes; leaves open whether perfusion-targeted therapies alter outcomes.
The pre-existing energetic deficit in diabetic cardiomyopathy is exacerbated by exercise; stress PCr/ATP correlates with impaired perfusion and oxygenation. Our findings suggest that, in diabetes, coronary microvascular dysfunction exacerbates derangement of cardiac energetics under conditions of increased workload.
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Levelt et al. (2015) studied this question.
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