The B7 family subgroup reflects tumor cell heterogeneity and patient post-operative prognosis in gallbladder cancer

Key Points

• To evaluate the role of B7 family expression in gallbladder cancer and its impact on post-operative prognosis.
• Analyzed B7-family expression in gallbladder cancer cell subpopulations.
• Investigated the signaling pathway involving HHLA2, RAC1, CDC42, PAK1, and Cofilin.
• Developed a GBM model based on tumor size and differentiation for risk stratification.
• Identified distinct GBC subpopulations based on B7-family markers.
• HHLA2 expression was linked to increased EMT and cell motility.
• The model indicated potential for improved post-operative risk assessment.