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This research aims to evaluate the feasibility of using a clinical proton synchrocyclotron for ultrahigh-dose-rate spatially fractionated radiotherapy.

April 23, 2026Physics in Medicine and Biology1 citationsOpen Access

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Feasibility of proton ultra-high-dose-rate spatially fractionated radiotherapy system for preclinical experiments on a compact proton synchrocyclotron

JSJufri SetianegaraKansai Medical University AWAoxiang WangKansai Medical University WLWangyao Li

Key Points

This research aims to evaluate the feasibility of using a clinical proton synchrocyclotron for ultrahigh-dose-rate spatially fractionated radiotherapy.
Demonstrated FLASH-SFRT irradiations using a clinical proton synchrocyclotron.
Utilized a brass collimator for targeted delivery.
Achieved specific spot trajectories over each aperture.
Successfully performed FLASH-SFRT irradiations.
Proton UHDRs were effectively achieved.
Targeted spot trajectories improved precision of treatment.

Abstract

In this work, we demonstrated that FLASH-SFRT irradiations can be performed on a clinical proton synchrocyclotron with a brass collimator. Proton UHDRs can be achieved with targeted spot trajectories over each aperture.

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Feasibility of proton ultra-high-dose-rate spatially fractionated radiotherapy system for preclinical experiments on a compact proton synchrocyclotron

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