Feasibility of proton ultra-high-dose-rate spatially fractionated radiotherapy system for preclinical experiments on a compact proton synchrocyclotron

Key Points

• This research aims to evaluate the feasibility of using a clinical proton synchrocyclotron for ultrahigh-dose-rate spatially fractionated radiotherapy.
• Demonstrated FLASH-SFRT irradiations using a clinical proton synchrocyclotron.
• Utilized a brass collimator for targeted delivery.
• Achieved specific spot trajectories over each aperture.
• Successfully performed FLASH-SFRT irradiations.
• Proton UHDRs were effectively achieved.
• Targeted spot trajectories improved precision of treatment.