Study on the mechanism of italicPiping Zhiyang Lotion /italic（皮平止痒洗剂） in ameliorating atopic dermatitis in mice

Key Points

• The research aims to explore the mechanism by which Piping Zhiyang Lotion alleviates atopic dermatitis in mice through network pharmacology and molecular docking.
• Utilized databases to identify active components and targets related to Piping Zhiyang Lotion and atopic dermatitis.
• Conducted GO and KEGG enrichment analysis on identified targets using DAVID database.
• Administered interventions in a mouse model of atopic dermatitis over a 29-day period, with analyses on Day 29.
• Identified 220 active components of Piping Zhiyang Lotion and 342 intersecting targets related to atopic dermatitis.
• Found that Piping Zhiyang Lotion significantly inhibits the activation of MAPK and other signaling pathways related to atopic dermatitis.
• Suggested that the lotion’s effects are linked to its multi-component, multi-target, and multi-pathway intervention characteristics.