Study on the mechanism of Piping Zhiyang Lotion （皮平止痒洗剂） in ameliorating atopic dermatitis in mice

April 1, 2026Lishizhen medicine and materia medica research

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Key Points

The research aims to explore the mechanism by which Piping Zhiyang Lotion alleviates atopic dermatitis in mice through network pharmacology and molecular docking.
Utilized databases to identify active components and targets related to Piping Zhiyang Lotion and atopic dermatitis.
Conducted GO and KEGG enrichment analysis on identified targets using DAVID database.
Administered interventions in a mouse model of atopic dermatitis over a 29-day period, with analyses on Day 29.
Identified 220 active components of Piping Zhiyang Lotion and 342 intersecting targets related to atopic dermatitis.
Found that Piping Zhiyang Lotion significantly inhibits the activation of MAPK and other signaling pathways related to atopic dermatitis.
Suggested that the lotion’s effects are linked to its multi-component, multi-target, and multi-pathway intervention characteristics.

Demonstrates the mechanism of Piping Zhiyang Lotion in reducing atopic dermatitis in mice, suggesting a multi-target intervention approach.

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GAO et al. (2026) studied this question.

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