Separable Syn/Anti Dinuclear Co(II) Macrocycles as Robust High-Performance paraCEST MRI Probes

Key Points

• The aim is to explore the effects of conformational control on the performance of dinuclear Co(II) macrocycles as MRI probes.
• Synthesis of separable isomer pairs of Co(II) macrocycles.
• Evaluation of their performance in paraCEST (chemical exchange saturation transfer) MRI applications.
• Assessment of structure-property relationships through MRI signal analysis.
• Enhanced MRI performance was observed with specific conformations of the macrocycles.
• Isolation of isomer pairs allowed for clear structure-property correlations.
• The findings suggest improved functionality in aqueous environments for certain isomers.