What question did this study set out to answer?

The aim is to explore the effects of conformational control on the performance of dinuclear Co(II) macrocycles as MRI probes.

April 24, 2026Inorganic Chemistry Frontiers1 citations

Separable Syn/Anti Dinuclear Co(II) Macrocycles as Robust High-Performance paraCEST MRI Probes

XGXin GuoBeijing Institute of Technology MQMao-Song QiuWuhan Institute of Physics and Mathematics JHJie-Sheng HuBeijing Institute of Technology

Key Points

The aim is to explore the effects of conformational control on the performance of dinuclear Co(II) macrocycles as MRI probes.
Synthesis of separable isomer pairs of Co(II) macrocycles.
Evaluation of their performance in paraCEST (chemical exchange saturation transfer) MRI applications.
Assessment of structure-property relationships through MRI signal analysis.
Enhanced MRI performance was observed with specific conformations of the macrocycles.
Isolation of isomer pairs allowed for clear structure-property correlations.
The findings suggest improved functionality in aqueous environments for certain isomers.

Abstract

Conformational control is a powerful strategy for programming function in coordination chemistry, yet isolable isomer pairs that enable clean structure–property correlations remain uncommon for aqueous first-row transition-metal systems. Here we...

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