Dual-action peptide shuttles rescue Cu-amyloid-Β-induced neurotoxicity and relocate Cu intracellularly

Key Points

• The research aims to explore how dual-action peptide shuttles mitigate neurotoxicity caused by copper-amyloid-β.
• Utilized dual-action peptide shuttles targeting Cu-induced toxicity
• Assessed intracellular copper relocation
• Evaluated neurotoxicity in cellular models of Alzheimer's disease
• Peptide shuttles significantly reduced neurotoxicity
• Observed enhanced relocation of copper intracellularly
• Confirmed interaction with tau protein and amyloid-β pathways