Dual-action peptide shuttles rescue Cu-amyloid-Β-induced neurotoxicity and relocate Cu intracellularly

Michael Okafor; David Schmitt; Enrico Falcone; Stéphane Gasman; Laurent Raibaut; Christelle Hureau; Peter Faller; Nicolas Vitale

doi:10.1039/d6qi00862c

January 1, 2026Inorganic Chemistry FrontiersOpen Access

Dual-action peptide shuttles rescue Cu-amyloid-Β-induced neurotoxicity and relocate Cu intracellularly

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Key Points

The research aims to explore how dual-action peptide shuttles mitigate neurotoxicity caused by copper-amyloid-β.
Utilized dual-action peptide shuttles targeting Cu-induced toxicity
Assessed intracellular copper relocation
Evaluated neurotoxicity in cellular models of Alzheimer's disease
Peptide shuttles significantly reduced neurotoxicity
Observed enhanced relocation of copper intracellularly
Confirmed interaction with tau protein and amyloid-β pathways

Implication

Study demonstrates that peptide shuttles reduce neurotoxicity in Alzheimer's, suggesting a novel therapeutic approach.

Abstract

Alzheimer’s disease (AD) remains the most prevalent neurodegenerative disease characterized by intracellular neurofibrillary tangles of Tau protein and extracellular senile plaques build on Amyloid-β (Aβ) peptides. The latter result from...

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Cite This Study

Okafor et al. (2026) studied this question.

synapsesocial.com/papers/69fbe3aa164b5133a91a2eeb https://doi.org/10.1039/d6qi00862c

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Dual-action peptide shuttles rescue Cu-amyloid-Β-induced neurotoxicity and relocate Cu intracellularly

Key Points

Implication

Abstract

Discussion

Cite This Study

Dual-action peptide shuttles rescue Cu-amyloid-Β-induced neurotoxicity and relocate Cu intracellularly

Key Points

Implication

Abstract

Discussion

Cite This Study

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