Linker dependence of 1O2 generation by G4-binding tetra-imidazolium porphyrins

Key Points

• The aim is to evaluate the complexation of tetra-imidazolium porphyrins with G4 DNA and their stability.
• Synthesis of three water-soluble porphyrins with tetra-cationic imidazolium groups.
• Assessment of complexation with human telomeric G4 DNA via UV titration studies.
• Determination of complexation stability through comparative analysis.
• Porphyrins exhibited 10-fold higher complexation stability with G4 DNA.
• Increased binding affinity correlates with structural variations in linker chemistry.