Linker dependence of 1O2 generation by G4-binding tetra-imidazolium porphyrins

Çetin Çelik; Naoko Kakusho; Tianyu Xu; Sung Hwa Lee; Naoko Yoshizawa-Sugata; Hisao Masai; Yoko Yamakoshi

doi:10.1039/d6ob00581k

January 1, 2026Organic & Biomolecular ChemistryOpen Access

Linker dependence of 1O2 generation by G4-binding tetra-imidazolium porphyrins

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Key Points

The aim is to evaluate the complexation of tetra-imidazolium porphyrins with G4 DNA and their stability.
Synthesis of three water-soluble porphyrins with tetra-cationic imidazolium groups.
Assessment of complexation with human telomeric G4 DNA via UV titration studies.
Determination of complexation stability through comparative analysis.
Porphyrins exhibited 10-fold higher complexation stability with G4 DNA.
Increased binding affinity correlates with structural variations in linker chemistry.

Implication

Demonstrates complexation stability of porphyrins with G4 DNA, suggesting potential applications in gene regulation.

Abstract

Three water-soluble porphyrins with tetra-cationic imidazolium groups were synthesized and assessed for complexation with human telomeric guanine-quadruplex (G4) DNA. By UV titration studies, these porphyrins showed 10-fold higher complexation stability...

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Cite This Study

Çelik et al. (2026) studied this question.

synapsesocial.com/papers/6a0567fda550a87e60a20488 https://doi.org/10.1039/d6ob00581k

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Linker dependence of 1O2 generation by G4-binding tetra-imidazolium porphyrins

Key Points

Implication

Abstract

Discussion

Cite This Study

Linker dependence of 1O2 generation by G4-binding tetra-imidazolium porphyrins

Key Points

Implication

Abstract

Discussion

Cite This Study

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