IFE-based lysosome-targeted probe for different response behaviors to biothiols and bioimaging | Synapse
May 15, 2026
IFE-based lysosome-targeted probe for different response behaviors to biothiols and bioimaging
Key Points
This research aims to explore the interactions between biothiols and a lysosome-targeted probe for bioimaging applications.
Developed an IFE-based probe targeting lysosomes.
Evaluated response behaviors of cysteine, homocysteine, and glutathione in bioimaging context.
Analyzed the differential roles of biothiols in maintaining lysosomal activity.
The probe effectively localized in lysosomes, enhancing bioimaging accuracy.
Different biothiols exhibited distinct response behaviors with the probe, indicating their varied functional roles in lysosomes.
Abstract
Biothiols (Cys, Hcy, and GSH) are generated by reducing disulphide bonds with the help of proteolysis in lysosomes, meanwhile three biothiols play the different roles in preserving the optimal activity...