What question did this study set out to answer?

To develop a chemoselective method for reducing quinazolinones to dihydroquinazolinones using Red‐Al.

May 15, 2026

Red‐Al‐Mediated Chemoselective 2,3‐Reduction of Quinazolinones

Key Points

To develop a chemoselective method for reducing quinazolinones to dihydroquinazolinones using Red‐Al.
Utilized Red‐Al as a reductant under mild conditions.
Demonstrated broad substrate scope and gram-scale synthesis.
Performed downstream derivatization of the products.
Achieved moderate to good yields of dihydroquinazolinones.
Successfully demonstrated the method's generality with various substrates.
Highlighted the practicality of the protocol for synthetic applications.

Abstract

ABSTRACT A chemoselective protocol for the 2,3‐reduction of quinazolinones was developed using Red‐Al as the reductant. Under mild conditions, this method furnishes a diverse set of synthetically useful dihydroquinazolinones in moderate to good yields. The generality and practicality of the protocol were demonstrated by a broad substrate scope, gram‐scale synthesis, and downstream derivatization of the products.

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