Red‐Al‐Mediated Chemoselective 2,3‐Reduction of Quinazolinones

Key Points

• To develop a chemoselective method for reducing quinazolinones to dihydroquinazolinones using Red‐Al.
• Utilized Red‐Al as a reductant under mild conditions.
• Demonstrated broad substrate scope and gram-scale synthesis.
• Performed downstream derivatization of the products.
• Achieved moderate to good yields of dihydroquinazolinones.
• Successfully demonstrated the method's generality with various substrates.
• Highlighted the practicality of the protocol for synthetic applications.