Altering hemodynamic conditions and contractile state adjusted the duration of each phase of left ventricular systole in denervated dog hearts.
Hemodynamic conditions in left ventricular systole
Altering stroke volume, aortic pressure, heart rate, digitalis, and norepinephrine
Duration of each phase of left ventricular systole
The effects of altering stroke volume, aortic pressure and heart rate on the duration of each phase of left ventricular systole were investigated in a denervated dog heart. Augmenting stroke volume was found to prolong ejection, shorten the isovolumic period and had little or no effect on the duration of total systole. Elevating mean aortic blood pressure shortened ejection time, prolonged the isovolumic phase and either had no effect or decreased slightly the duration of total systole. Increasing heart rate at constant aortic pressure and stroke volume reduced the duration of all phases of systole. Digitalis and norepinephrine shortened all phases of systole. These findings demonstrate that the duration of each phase of left ventricular systole is dependent upon existing hemodynamic conditions as well as on the contractile state of the myocardium. By means of intrinsic mechanisms the ventricle exhibits the remarkable capability of being able to adjust the duration of each phase of systole in a manner appropriate to changing hemodynamic conditions.
Building similarity graph...
Analyzing shared references across papers
Loading...
Andrew G. Wallace
University of Greenwich
JERE H. MITCHELL
American Heart Association
N. Sheldon Skinner
National Institutes of Health
Circulation Research
United States Public Health Service
American Heart Association
Building similarity graph...
Analyzing shared references across papers
Loading...
Wallace et al. (Sat,) conducted a other in Hemodynamic conditions in left ventricular systole. Altering stroke volume, aortic pressure, heart rate, digitalis, and norepinephrine was evaluated on Duration of each phase of left ventricular systole. Altering hemodynamic conditions and contractile state adjusted the duration of each phase of left ventricular systole in denervated dog hearts.
synapsesocial.com/papers/6a07b4da44ff8ad339f69c55 — DOI: https://doi.org/10.1161/01.res.12.6.611
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: