May 1, 1958Open Access
Determinants of Duration and Mean Rate of Ventricular Ejection
Key Result
Various hemodynamic factors, hypothermia, and sympathomimetic amines were studied for their influence on the duration and mean rate of ventricular ejection in an isolated heart preparation.
PICO
Population
Isolated heart preparation
Intervention / Comparator
Alterations in stroke volume, heart rate, aortic pressure, hypothermia, sympathomimetic amines, valvular regurgitation, and myocardial contractility
Primary Outcome
Duration and mean rate of ventricular ejection and filling
Abstract
The independent influences of stroke volume, heart rate, aortic pressure, hypothermia, sympathomimetic amines, metered mitral and aortic valvular regurgitation, and alterations in myocardial contractility on the duration and mean rate of ventricular ejection and filling were studied. These observations were made in a metabolically supported, isolated heart preparation with performance characteristics comparable to the non-isolated heart.
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Authors
Eugene Braunwald
Boston University
S
Stanley J. Sarnoff
Washington University in St. Louis
W
W. N. Stainsby
National Institutes of Health
Journals
Circulation Research
Actions
Institutions
National Heart Lung and Blood Institute
References and Citations
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