Determinants of Duration and Mean Rate of Ventricular Ejection
Key result
Various hemodynamic factors, hypothermia, and sympathomimetic amines were studied for their influence on the duration and mean rate of ventricular ejection in an isolated heart preparation.
Population
Metabolically supported, isolated heart preparation
Comparison
Alterations in stroke volume, heart rate, aortic… vs Baseline or control states of the isolated heart…
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
May inform experimental designs in cardiovascular physiology; leaves open direct clinical translation from this isolated model.
Structured PICO
P
Population
Metabolically supported, isolated heart preparation
I
Intervention
Alterations in stroke volume, heart rate, aortic pressure, hypothermia, sympathomimetic amines, metered mitral and aortic valvular regurgitation, and myocardial contractility
C
Comparator
Baseline or control states of the isolated heart preparation
O
Outcome
Duration and mean rate of ventricular ejection and fillingsurrogate
This preclinical study identifies the independent physiological and pharmacological determinants of ventricular ejection and filling duration and rate in an isolated heart model.
Cite This Study
Braunwald et al. (1958) studied Isolated heart preparation. Alterations in stroke volume, heart rate, aortic pressure, hypothermia, sympathomimetic amines, valvular regurgitation, and myocardial contractility was evaluated on Duration and mean rate of ventricular ejection and filling. Various hemodynamic factors, hypothermia, and sympathomimetic amines were studied for their influence on the duration and mean rate of ventricular ejection in an isolated heart preparation.